A hotel housekeeper is responsible for maintaining a high level of cleanliness and comfort in guest rooms and common areas by cleaning, sanitizing, dusting, and vacuuming, making beds with fresh linens, replenishing amenities like toiletries and towels, and responding to guest requests. Housekeepers also report maintenance issues, manage laundry, and stock their housekeeping carts with necessary supplies, all while adhering to hotel standards and safety regulations.